Software with TPM 2.0 support

tpm2-tss
TPM2-Tools
PKCS11 (wip)
OpenSSL
OpenConnect Docs
cryptsetup/LUKS (wip)
StrongSwan
Clevis (Howto)
TPM2-TOTP
LVFS / fwupd: Post1, Post2

Projects requiring TPM 2.0 support

OpenVPN
WireGuard
Tinc
NetworkManager/wpa_supplicant 802.1X
gnome-keyring
KDE wallet
GNU-TLS
WebCrypto (Firefox, WebKit, Chromium, epiphany)
WebAuthn (Firefox, WebKit, Chromium)
OpenSSH HostKey ((non-)PKCS11), ClientKey ((non-)PKCS11)
Wireshark TPM Cmd/Rsp/Buffer with TCTI-PCAP module or /dev/tpmrm0 sniffing (partial, TPM-Headers only yet)
mbed-crypto / mbed-tls
OpenJDK keystore
Firefox/Thunderbird/Chromium/epiphany password managers: Epiphany via gnome-keyring ?
systemd-journald signing
systemd-networkd 802.1x
empathy/telepathy jabber (via PKCS11?)
GnuPG (also leads to git tag and release signing)
Telegram desktop
GNOME Keyring

Please feel free to also add notes to this list wrt means of integration, e.g. if a project could be enabled using tpm2-pkcs11 and p11-kit because it already provides a pkcs11 interfaces for authentication.